Endocrine Abstracts

Introduction: Overt hypothyroidism is associated with diastolic hypertension, but in subclinical hypothyroidism, data are inconclusive. HS tiroxina is a double-blind trial evaluating the effect of levothyroxine on blood pressure in patients with mild SH (TSH 5.0–9.9 mU/l and normal free T4) and moderate-to-high cardiovascular risk.Methods: We analized baseline data of the first 46 patients screened. Confirmatory thyroid function tests wer...

Context: Several specific transcriptional factors, in view of their important role in thyroid organogenesis and thyroid specific gene expression, would be strong candidate genes for the etiology of TD. The homeobox transcription factor NKX2.5 was thought to be only required for the organogenesis of the heart tube. However, NKX2.5−/− embryos also exhibited a smaller outgrowing thyroid bud. Indeed, several loss ...